206 lines
9.4 KiB
HTML
206 lines
9.4 KiB
HTML
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<!DOCTYPE HTML><html><head>
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<title>AndreaGenePanelsTest - Google Fusion Tables</title>
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<style type="text/css">
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html, body {
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margin: 0;
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padding: 0;
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height: 100%;
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}
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</style></head>
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<body><table cellpadding="0" cellspacing="0"><tr><td><div class="googft-card-view" style="font-family:sans-serif;width:450px;padding:4px;border:1px solid #ccc;overflow:hidden">
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<b>updated 5.23.14- ADF:</b> BRCA 1/2 (No Panel)<br>
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<b>col1:</b> <br>
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<b>col2:</b> <br>
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<b>col3:</b> <br>
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<b>col4:</b> <br>
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<b>col5:</b> <br>
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<b>col6:</b> <br>
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<b>col7:</b> <br>
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<b>col8:</b> <br>
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<b>col9:</b> <br>
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<b>col10:</b> <br>
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<b>col11:</b>
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</div></td> <td><div class="googft-card-view" style="font-family:sans-serif;width:450px;padding:4px;border:1px solid #ccc;overflow:hidden">
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<b>updated 5.23.14- ADF:</b> Company / Lab<br>
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<b>col1:</b> Myriad Genetics- UT<br>
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<b>col2:</b> Ambry Genetics-CA<br>
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<b>col3:</b> GeneDX-MD<br>
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<b>col4:</b> UW- WA<br>
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<b>col5:</b> Quest<br>
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<b>col6:</b> LabCorp<br>
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<b>col7:</b> Invitae<br>
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<b>col8:</b> Gene by Gene<br>
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<b>col9:</b> Baylor<br>
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<b>col10:</b> Counsyl<br>
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<b>col11:</b> DNA Traits-TX
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</div></td></tr> <tr><td><div class="googft-card-view" style="font-family:sans-serif;width:450px;padding:4px;border:1px solid #ccc;overflow:hidden">
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<b>updated 5.23.14- ADF:</b> BRCA1/2 COMPLETE<br>
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<b>col1:</b> $4,040<br>
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<b>col2:</b> $2,200<br>
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<b>col3:</b> $2,200<br>
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<b>col4:</b> $2,200<br>
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<b>col5:</b> $2,495<br>
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<b>col6:</b> $2,895<br>
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<b>col7:</b> $1,500<br>
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<b>col8:</b> $995 (seq only)<br>
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<b>col9:</b> $1499 ($999 self-pay) (Counsyl)<br>
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<b>col10:</b> $2,499<br>
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<b>col11:</b> $995
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</div></td> <td><div class="googft-card-view" style="font-family:sans-serif;width:450px;padding:4px;border:1px solid #ccc;overflow:hidden">
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<b>updated 5.23.14- ADF:</b> del/dup alone<br>
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<b>col1:</b> $700<br>
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<b>col2:</b> $500<br>
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<b>col3:</b> $1,000<br>
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<b>col4:</b> $1,000<br>
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<b>col5:</b> $500<br>
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<b>col6:</b> $700<br>
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<b>col7:</b> n/a<br>
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<b>col8:</b> <br>
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<b>col9:</b> <br>
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<b>col10:</b> $399<br>
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<b>col11:</b> ??
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</div></td></tr> <tr><td><div class="googft-card-view" style="font-family:sans-serif;width:450px;padding:4px;border:1px solid #ccc;overflow:hidden">
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<b>updated 5.23.14- ADF:</b> AJ3<br>
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<b>col1:</b> $575<br>
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<b>col2:</b> $500<br>
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<b>col3:</b> $450<br>
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<b>col4:</b> $550<br>
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<b>col5:</b> $500<br>
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<b>col6:</b> $600<br>
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<b>col7:</b> n/a<br>
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<b>col8:</b> <br>
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<b>col9:</b> <br>
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<b>col10:</b> <br>
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<b>col11:</b> $150
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</div></td> <td><div class="googft-card-view" style="font-family:sans-serif;width:450px;padding:4px;border:1px solid #ccc;overflow:hidden">
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<b>updated 5.23.14- ADF:</b> SingleSite<br>
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<b>col1:</b> $475<br>
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<b>col2:</b> $400<br>
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<b>col3:</b> $350/1 mut. or $500/2 mut.<br>
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<b>col4:</b> $450<br>
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<b>col5:</b> $500<br>
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<b>col6:</b> $500<br>
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<b>col7:</b> $200<br>
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<b>col8:</b> <br>
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<b>col9:</b> <br>
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<b>col10:</b> <br>
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<b>col11:</b> $70
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</div></td></tr> <tr><td><div class="googft-card-view" style="font-family:sans-serif;width:450px;padding:4px;border:1px solid #ccc;overflow:hidden">
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<b>updated 5.23.14- ADF:</b> TAT<br>
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<b>col1:</b> <2 weeks<br>
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<b>col2:</b> 2 weeks<br>
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<b>col3:</b> 8-10 days<br>
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<b>col4:</b> 8-12wks<br>
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<b>col5:</b> 2 weeks pre-auth + 2 weeks<br>
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<b>col6:</b> 2 weeks pre-auth + 12-21 days<br>
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<b>col7:</b> 2-3 weeks<br>
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<b>col8:</b> <br>
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<b>col9:</b> <2 weeks<br>
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<b>col10:</b> <br>
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<b>col11:</b> 3 weeks, will soon be reduced to 2
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</div></td> <td><div class="googft-card-view" style="font-family:sans-serif;width:450px;padding:4px;border:1px solid #ccc;overflow:hidden">
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<b>updated 5.23.14- ADF:</b> Specimen Type(s)<br>
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<b>col1:</b> Blood or saliva<br>
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<b>col2:</b> Blood or Saliva<br>
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<b>col3:</b> Blood.<br>
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<b>col4:</b> Blood<br>
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<b>col5:</b> Blood<br>
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<b>col6:</b> Blood<br>
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<b>col7:</b> Blood<br>
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<b>col8:</b> <br>
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<b>col9:</b> Blood<br>
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<b>col10:</b> <br>
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<b>col11:</b> Blood or saliva. Prefer buccal cell kits.
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</div></td></tr> <tr><td><div class="googft-card-view" style="font-family:sans-serif;width:450px;padding:4px;border:1px solid #ccc;overflow:hidden">
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<b>updated 5.23.14- ADF:</b> VUS Rate<br>
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<b>col1:</b> 2-3%<br>
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<b>col2:</b> 4.4%<br>
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<b>col3:</b> <br>
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<b>col4:</b> <br>
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<b>col5:</b> <br>
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<b>col6:</b> <br>
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<b>col7:</b> 6%<br>
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<b>col8:</b> <br>
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<b>col9:</b> <br>
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<b>col10:</b> <br>
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<b>col11:</b>
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</div></td> <td><div class="googft-card-view" style="font-family:sans-serif;width:450px;padding:4px;border:1px solid #ccc;overflow:hidden">
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<b>updated 5.23.14- ADF:</b> Variant Program<br>
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<b>col1:</b> Yes - Variant Classification Program. Variants reviewed daily. www.myriadpro.com/for-your-practice/myvision-2/<br>
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<b>col2:</b> Yes - Family Studies Program (free testing to informative relatives)<br>
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<b>col3:</b> yes<br>
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<b>col4:</b> Yes - Family Studies Program (free testing to informative relatives)<br>
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<b>col5:</b> Website alludes to family testing, but no formal policy
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Partner with Informed DNA GCs to help with variant classification<br>
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<b>col6:</b> unknown<br>
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<b>col7:</b> Yes- Free testing to informative relatives<br>
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<b>col8:</b> <br>
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<b>col9:</b> Unknown. Testing done at Counsyl. Sanger confirmation not performed.<br>
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<b>col10:</b> VUS classified using publically available databases and ACMG guidelines<br>
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<b>col11:</b> Reports VUS rate of ~5% or less.
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</div></td></tr> <tr><td><div class="googft-card-view" style="font-family:sans-serif;width:450px;padding:4px;border:1px solid #ccc;overflow:hidden">
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<b>updated 5.23.14- ADF:</b> Financial Assistance?<br>
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<b>col1:</b> yes. 24-mo interest-free payment plan<br>
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<b>col2:</b> Yes. Also, 10% discount if paid in full.<br>
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<b>col3:</b> Financial Assistance available.<br>
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<b>col4:</b> 15% discount for self-pay in paid in total. No charity care.<br>
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<b>col5:</b> yes<br>
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<b>col6:</b> ??<br>
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<b>col7:</b> Yes<br>
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<b>col8:</b> <br>
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<b>col9:</b> <br>
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<b>col10:</b> <br>
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<b>col11:</b> Requires pre-payment, no insurance accepted
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</div></td> <td><div class="googft-card-view" style="font-family:sans-serif;width:450px;padding:4px;border:1px solid #ccc;overflow:hidden">
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<b>updated 5.23.14- ADF:</b> Preverification?<br>
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<b>col1:</b> yes. Patients notified if out of pocket cost over $375.<br>
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<b>col2:</b> Yes. Patients notified if out of pocket cost over $100.<br>
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<b>col3:</b> Benefit Investigation is performed using in-network lab benefits and patients are notified if OOP is over $100<br>
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<b>col4:</b> Yes<br>
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<b>col5:</b> yes<br>
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<b>col6:</b> yes<br>
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<b>col7:</b> yes<br>
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<b>col8:</b> <br>
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<b>col9:</b> yes<br>
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<b>col10:</b> <br>
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<b>col11:</b> Yes. Working on becoming an in-network provider.
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</div></td></tr> <tr><td><div class="googft-card-view" style="font-family:sans-serif;width:450px;padding:4px;border:1px solid #ccc;overflow:hidden">
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<b>updated 5.23.14- ADF:</b> Technology<br>
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<b>col1:</b> Bidirectional sequencing with repeat analysis of clinically significant variants. Rearrangement analysis with either multiplex PCR or microarray CGH to determine copy number abnormalities.<br>
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<b>col2:</b> Single gene sequencing for BRCA1/2 and panels listed below are performed using next-generation sequencing (NGS) and deletion/duplication (ie. large rearrangement) analyses is performed using MLPA or aCGH microarray.<br>
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<b>col3:</b> Genomic DNA enriched for the complete coding region and splice site junctions of the 26 genes using ureSelect targeted capture. Sequenced on an Illumina MiSeq instrument with 2x150 paired-end reads. Capillary sequencing is used to confirm all potentially pathogenic variants identified by sequencing and to fill-in sequence for low coverage regions. Exon-level oligo array CGH is performed concurrently for all the genes in the panel. Confirmation of copy number changes is performed by MLPA, qPCR, or repeat aCGH analysis.<br>
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<b>col4:</b> The assay completely sequences all exons and flanking introns of these genes AND detects large deletions, duplications, and mosaicism.<br>
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<b>col5:</b> NGS with MLPA for del/dup<br>
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<b>col6:</b> <br>
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<b>col7:</b> <br>
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<b>col8:</b> <br>
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<b>col9:</b> NGS with del/dup<br>
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<b>col10:</b> Uses "ultra deep" NGS for both sequence variants and large del/dup<br>
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<b>col11:</b> Sanger-sequencing to sequencing the full genes plus ~50bp into the intronic regions to insure full coverage of the genes. Multiplexed ligation probe amplification (MLPA) for the large rearrangement testing. Actively working to continue iterating on our cost optimization and sequencing technologies, and we hope to be able to run the test with the Illumina HiSeq platform in the coming months, which will allow us to yet again significantly reduce the price. We absolutely have the highest quality sequencing data produced.
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</div></td> <td><div class="googft-card-view" style="font-family:sans-serif;width:450px;padding:4px;border:1px solid #ccc;overflow:hidden">
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<b>updated 5.23.14- ADF:</b> Sanger confirmation?<br>
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<b>col1:</b> N/A<br>
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<b>col2:</b> Yes<br>
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<b>col3:</b> <br>
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<b>col4:</b> <br>
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<b>col5:</b> No, confirmation by another NGS method<br>
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<b>col6:</b> <br>
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<b>col7:</b> <br>
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<b>col8:</b> <br>
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<b>col9:</b> <br>
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<b>col10:</b> No<br>
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<b>col11:</b>
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</div></td></tr> <tr><td><div class="googft-card-view" style="font-family:sans-serif;width:450px;padding:4px;border:1px solid #ccc;overflow:hidden">
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<b>updated 5.23.14- ADF:</b> Analytical Sensitivity<br>
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<b>col1:</b> >99.92<br>
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<b>col2:</b> >99%<br>
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<b>col3:</b> >99%<br>
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<b>col4:</b> >99%<br>
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<b>col5:</b> >99%<br>
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<b>col6:</b> unknown<br>
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<b>col7:</b> >99%<br>
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<b>col8:</b> <br>
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<b>col9:</b> <br>
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<b>col10:</b> <br>
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<b>col11:</b> tbd
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</div></td></tr></table></body></html>
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